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MSN 513

Micro and Nanostructured Sensors and Biosensing Applications

MSN 513 is about turning biological recognition events—an antibody binding its antigen, an enzyme cleaving a substrate, a strand of DNA finding its complement—into measurable electrical, optical, or mechanical signals at the micro and nanoscale, and understanding why every choice from surface chemistry to transducer geometry shapes what you can actually detect. You'll work through the full sensor stack via lectures, two quizzes, a midterm and final, and a term project where you design or critique a real biosensing scheme end-to-end. As a graduate elective it sits at the intersection of MEMS, materials, and bioengineering, and it's the natural bridge for anyone heading into point-of-care diagnostics, lab-on-chip research, or nanophotonic sensing.

Credit3ECTS5BölümMaterials Science and Nanotechnology

Değerlendirme 100% — 5 adım

20%
25%
25%
20%
10%
Midterm Midterm 20%
Final Exam Final Exam 25%
Term Project Term Project 25%
Quiz Quiz 20%
In-class participation In-class participation 10%

Haftalık müfredat 14 hafta

Hafta 1
Course overview. Introductory concepts on sensors and transducers, historical development, and recent advances. Fundamental aspects of transduction: throughput, dynamic range, limit of detection, limit of quantitation, labelling/label-free strategies, and signal enhancement.
Hafta 2
Bioreceptors and molecular recognition: enzymes, antibodies, carbohydrates, nucleic acids, aptamers, lipids, and molecularly imprinting polymers.
Hafta 3
Surface chemistry approaches: surface functionalization, immobilization of biologically and chemically active groups.
Hafta 4
Characterization tools and analysis.
Hafta 5
Nanoparticle-based sensing and imaging strategies: paper-based assays, lateral flow assays, targeted imaging particles, and so on.
Hafta 6
Optical sensing modalities: surface plasmon resonance, photonic crystals, SERS, whispering gallery mode, etc.
Hafta 7
Electrochemical sensing strategies: amperometric, voltammetric, conductometric, impedimetric, and potentiometric sensors.
Hafta 8
Mechanical/Acoustic sensing strategies: cantilever-based systems, quartz crystal microbalance, and so on.
Hafta 9
Integrative systems: microfluidics and lab-on-chip systems.
Hafta 10
Integrative systems: smart materials and whole-cell machinery
Hafta 11
Application: medical diagnostics (point-of-care, point-of-need, non-invasive and rapid tests).
Hafta 12
Application: sensing strategies for environmental monitoring, food/water safety and allergens.
Hafta 13
Application: sensors for security.
Hafta 14
Future perspective on sensors: miniaturizing and simplifying sensors for daily-use.

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Geçmiş GPA dağılımı 9 dönem · ort. 3.71

DönemCourse CPA
2023-2024 Fall 3.67 1 sec · 12 öğr
2022-2023 Fall 3.64 1 sec · 19 öğr
2021-2022 Fall 3.51 1 sec · 28 öğr
2020-2021 Fall 3.61 1 sec · 20 öğr
2016-2017 Fall 3.49 1 sec · 22 öğr
2015-2016 Fall 3.90 1 sec · 6 öğr
2011-2012 Spring 3.84 1 sec · 12 öğr
2010-2011 Spring 3.76 1 sec · 31 öğr
2008-2009 Fall 3.93 1 sec · 18 öğr

Aggregate course GPA — Bilkent STARS'tan public data. Hoca-bazlı per-section detayı için STARS evaluation report →. Öğrenci anket cevapları KVKK kapsamında defter'de tutulmaz.

⚠️ FZ engelleyen şartlar

Course Learning Outcomes: Course Learning Outcome Assessment Develop the concept of a sensor, and other related fundamental concepts such as signal to noise ratio, resolution, sensitivity, linearity and limit of detection Midterm Final Exam Term Project Quiz Develop basic understanding of MEMS fabrication processes Midterm Final Exam Term Project Quiz Learn about mechanical design elements, and lumped models. Learn about piezoelectric, capacitive and piezoresistive sensing. Midterm Final Exam Te

Hocalar 1 bu dönem · 1 geçmiş

Bu dönem (2025-2026 Spring) · 1 section
Fatih İnci
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