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CHEM 534

NMR Spectroscopy for Organic Structure Determination

NMR is the workhorse tool organic chemists use to figure out what a molecule actually looks like, and this course is about reading those spectra fluently enough to deduce an unknown structure from scratch. You'll spend most of your time interpreting 1H and 13C spectra — reasoning about chemical shifts, coupling patterns, spin systems, and NOE signals — and assembling those clues into a coherent structural argument, with two written midterms testing how well you can do it under time pressure. It assumes you already know your organic functional groups cold, and pays off the moment you hit a research lab where every new compound you make lands on the NMR before anything else.

Credit3ECTS5FacultyFaculty of ScienceBölümChemistry

Değerlendirme 50% — 1 adım

50%
Midterm:Essay/written Midterm 50%

Önerilen kaynaklar 3 kitap

📕
Zorunlu
Basic 1H-13C-NMR Spectroscopy
Metin Balcı
2005 · 1st Edition
📖
Önerilen
High-Resolution NMR Techniques in Organic Chemistry
Timothy D. W. Claridge
2016 · 3rd Edition
📖
Önerilen
Understanding NMR Spectroscopy
James Keeler
2016 · 2nd Edition

Haftalık müfredat 14 hafta

Hafta 1
Introduction to Nuclear Magnetic Resonance (NMR) Spectroscopy
Hafta 2
Resonance Phenomena in NMR Spectroscopy
Hafta 3
Chemical Shifts
Hafta 4
Spin-Spin Coupling in 1H-NMR Spectroscopy
Hafta 5
Spin-Spin Coupling to Different Protons
Hafta 6
Spin Systems and Second-Order Spectra - I
Hafta 7
Spin Systems and Second-Order Spectra - II
Hafta 8
13C-NMR Spectroscopy – Introduction
Hafta 9
Pulse NMR Spectroscopy
Hafta 10
Chemical Shifts in 13C-NMR Spectroscopy
Hafta 11
Spin-Spin Coupling in 13C-NMR Spectroscopy
Hafta 12
The Nuclear Overhauser Effect
Hafta 13
Other Nuclei in NMR Spectroscopy
Hafta 14
Strategies for the Structure Determination of Unknown Compounds

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Course Learning Outcomes: Course Learning Outcome Assessment Able to apply knowledge of fundamental principles of NMR spectroscopy to organic structure determination. Midterm Homework Final:Essay/written Able to relate chemical shifts in 1H- and 13C-NMR spectroscopy with various organic functional groups. Midterm Homework Final:Essay/written Able to describe and identify concepts of spin-spin coupling, spin systems and the nuclear Overhauser effect. Midterm Homework Final:Essay/written Able to d

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