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MBG 326

Introduction to Bioinformatics

MBG 326 is where molecular biology meets the command line: you learn to treat sequences, expression matrices, and genomes as data you can actually query, align, and model rather than just memorize. Most of the work happens in R — weekly labs and five homeworks walk you through tidyverse, ggplot2, clustering, PCA, and eventually a full RNA-seq project, scaffolded by Akalin's Computational Genomics with R. It's the course that turns the wet-lab intuition from earlier MBG classes into the computational fluency you'll need for genomics electives, thesis work, or anything downstream of a sequencer.

Credit3ECTS5FacultyFaculty of ScienceBölümMolecular Biology and Genetics

Değerlendirme 95% — 5 adım

10%
20%
25%
20%
20%
Homework Datacamp assignments and lab attendance 10%
Midterm:Essay/written Midterm I, Midterm II 40%
Final:Essay/written Final Exam (Comprehensive) 25%
Quiz Moodle or in class Quiz on lab material/worksheets 20%

Önerilen kaynaklar 2 kitap

📕
Zorunlu
Weekly readings will be announced Required - Web Link: datacamp
📕
Zorunlu
Computational Genomics with R
Altuna Akalin
1st edition · selected chapters

Haftalık müfredat 14 hafta

Hafta 1
Syllabus; Introduction: cells; DNA, RNA, protein: genetics, replication, transcription, translation. Book: Computational Genomics with R, Chapter 1. Additional Reviews.
Hafta 2
R programming basics lab: scalars, vectors, matrices, lists and indexing. Computational Genomics with R, Chapter 2.1-2.6.
Hafta 3
HOMEWORK 1a: Introduction to R and Rmarkdown; R programming basics: basic plotting and ggplot2; Databases: NCBI, Ensembl, UCSC, BLAST; sequence alignment; Computational Genomics with R, Chapter 2.6-2.9; Molecular Biology and Bioinformatics Article Readings on Moodle
Hafta 4
QUIZ 1. Introduction to R (vectors, scalars, matrices, lists, factors and basic stats and plotting); Computational Genomics with R, Chapter 3: Statistics for Genomics
Hafta 5
HOMEWORK Ib: tidyverse; R programming basics lab: ggplot2 and dplyr; Molecular Biology and Bioinformatics Article Readings on Moodle
Hafta 6
QUIZ 2: dplyr, ggplot2; R programming basics:I ntermediate R (conditionals, loops and apply); Clustering and Dimension Reduction. Comparative Genomics with R, Chapter 4.
Hafta 7
HOMEWORK II: Unsupervised clustering; Molecular Biology and Bioinformatics Article Readings on Moodle; programming basics lab: Writing Functions in R;
Hafta 8
MIDTERM I (writen/essay-closed book, weeks 1-8); kmedoids, PCA
Hafta 9
HOMEWORK III: intermediate R; Computation Genomics with R, Chapter 5.
Hafta 10
HOMEWORK IV: Machine Learning and Prediction; Readings from molecular biology and bioinformatics literature
Hafta 11
QUIZ 3: limma and unsupervised learning; Genomics with R, Chapter 7; Sequencing and QC
Hafta 12
MIDTERM II (written/essay-closed book, weeks 7-12); Machine Learning, Reading MultiOmics
Hafta 13
HOMEWORK V: RNAseq analysis; Next Generation Sequencing and applications. Computational Genomics with R, Chapter 8. RNAseq preprocessing and analyses and annotation on RNAseq analyses and Advanced Topics; RNAseq project and presentation prep
Hafta 14
QUIZ4: RNAseq and machine learning; Machine learning; RNAseq project data selection and prep for presentation

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MBG 326 için defter ekibi henüz not yazmadı.

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Geçmiş GPA dağılımı 19 dönem · ort. 3.00

DönemCourse CPA
2025-2026 Fall 3.02 1 sec · 58 öğr
2024-2025 Fall 2.89 1 sec · 63 öğr
2023-2024 Fall 3.09 1 sec · 53 öğr
2022-2023 Fall 3.41 1 sec · 43 öğr
2021-2022 Fall 2.64 1 sec · 35 öğr
2020-2021 Fall 3.25 1 sec · 65 öğr
2019-2020 Fall 2.75 1 sec · 66 öğr
2018-2019 Fall 2.73 1 sec · 59 öğr
2017-2018 Fall 2.88 2 sec · 85 öğr
2016-2017 Fall 2.87 1 sec · 52 öğr

Aggregate course GPA — Bilkent STARS'tan public data. Hoca-bazlı per-section detayı için STARS evaluation report →. Öğrenci anket cevapları KVKK kapsamında defter'de tutulmaz.

⚠️ FZ engelleyen şartlar

to have two midterm grades; IMPORTANT NOTE: this course is BIOLOGICAL in nature. There will be NO CHEATSHEETS provided in midterms or the final. There will be at least one hour/week lab hour that you need to attend. This course requires a VERY GOOD understanding of molecular biology and genetics and their applications. There will be biological research articles that use bioinformatics for additional reading, which will be on the exams.

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