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MBG 489

Genetics and Biology of Cancer

Cancer is fundamentally a disease of broken genetic circuitry, and this course traces how normal cells accumulate the mutations and signaling failures that turn them malignant — from oncogene activation and tumor suppressor loss to the way tumors recruit blood supply, evade immunity, and metastasize. You'll work through Weinberg chapter by chapter, present primary literature to the class, and tackle homeworks and quizzes that push you past memorization toward proposing your own hypotheses. Building on the molecular biology and genetics core, it ties those mechanisms to real disease and sets up later work in immunotherapy, drug discovery, and translational research.

Credit3ECTS5FacultyFaculty of ScienceBölümMolecular Biology and Genetics

Değerlendirme 100% — 5 adım

30%
10%
10%
20%
30%
Midterm Essay/written 30%
Homework Essay/written 10%
Quiz Essay/written 10%
Presentations Oral 20%
Final Essay/written 30%

Önerilen kaynaklar 1 kitap

📕
Zorunlu
The Biology of Cancer
Weinberg
2012/2nd edition

Haftalık müfredat 14 hafta

Hafta 1
The Nature of Cancer (Weinberg, Chapter 2)
Hafta 2
Tumor Viruses and Cellular Oncogenes (Weinberg, Chapter 3 and 4)
Hafta 3
Oral presentations related to Chapter 3 and 4
Hafta 4
Growth Factor Receptors and Cytoplasmic Signaling Circuits in Cancer (Weinberg, Chapter 5 and 6)
Hafta 5
Oral presentations related to Chapter 5 and 6
Hafta 6
Tumor Suppressor Genes: pRB, p53 (Weinberg, Chapter 7, 8 and 9)
Hafta 7
Oral presentations related to Chapter 7, 8 and 9
Hafta 8
Cell Immortalization, Maintaining Genomic Integrity and Multistep Tumorigenesis (Weinberg, Chapter 10, 11 and 12)
Hafta 9
Oral presentations related to Chapter 10, 11 and 12
Hafta 10
Heterotypic Interactions, Angiogenesis, Invasion and Metastasis (Weinberg, Chapter 13 and 14)
Hafta 11
Oral presentations related to Chapter 13 and 14
Hafta 12
Tumor Immunology and Immunotherapy (Weinberg, Chapter 15)
Hafta 13
Rational Treatment of Cancer (Winberg, Chapter 16)
Hafta 14
Oral presentations related to Chapter 15 and 16

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MBG 489 için defter ekibi henüz not yazmadı.

İlk dosyayı sen atarsan — not, slayt, geçmiş sınav, çözüm, cheat-sheet, ne varsa — defter ekibi öğrenci paylaşımlarından bu dersin notlarını yazar. Drive linki / PDF / ZIP, hepsi olur.

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⚠️ FZ engelleyen şartlar

You have to attend at least 70% of the classes. You have to score a minimum of 50% from all other parts (MTs, quizzes, homeworks) except from presentations, final and attendance. Coming late is not appreciated (Max 15 min late for three classes at most).

Hocalar 0 bu dönem · 3 geçmiş

Geçmişte ders veren (3 kişi)
İlyas Chachoua, Serkan İsmail Göktuna, Mehmet Öztürk