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MBG 418

Genomics

Genomics is where you stop thinking about single genes and start treating entire genomes as data — figuring out how to actually pull biological meaning out of the firehose of sequence reads that modern instruments produce. Most weeks pair a lecture on a sub-area (comparative, meta-, epi-, cancer, systems) with a hands-on lab in Galaxy, Ensembl, UCSC, GNOMAD, VEP, IGV, or cBioPortal, plus two midterms, lab quizzes, and a presentation. It sits downstream of molecular biology and biochemistry and is essentially the bridge into bioinformatics-heavy research, so anyone considering a thesis in MBG or a computational-biology track ends up leaning on these skills constantly.

Credit4ECTS6.5FacultyFaculty of ScienceBölümMolecular Biology and Genetics

Değerlendirme 100% — 4 adım

42%
24%
24%
10%
Midterm Midterm 42%
Final 1 Final 24%
Lab work 8 topics computer based labs (2 points for worksheet and 1 point for each quiz) 24%
In-class attendance in-class participation. 10%

Önerilen kaynaklar 1 kitap

📖
Önerilen
Genomes 4

Haftalık müfredat 14 hafta

Hafta 1
Genomes, Genome Browsers, Databases, Syllabus; Lab1a: GNOMAD
Hafta 2
DNA/Protein variation and Next Generation Sequencing Technologies; LAB 1b: Ensembl Biomart
Hafta 3
Next Generation Sequencing Analysis Basics; LAB2a: UCSC Genome Browser Tracks and Galaxy Basics I
Hafta 4
Prokaryotic, Viral and Eukaryotic Genomes, Metagenomics; MIDTERM 1 (in class 50 mins); LAB2b: Galaxy Basics II
Hafta 5
Metagenomics Analysis I; LAB3a: Metagenomics 16S fastq paired end data and quality control and data processing
Hafta 6
Metagenomics Analysis II: LAB3b: metagenomics analysis clustering and visualization
Hafta 7
Comparative Genomics/Transcriptomics; Spring Break; LAB4a: NGS I in galaxy;
Hafta 8
Human Genome Variation GWAS; MIDTERM 2-3 in class (100 mins); LAB4b: NGS II in galaxy
Hafta 9
Cancer Genomics; LAB5a: GWAS Catalog and VEP; LAB QUIZ 1 (labs 1-3); LAB 4c: NGS III
Hafta 10
Epigenomics and Cistrome; LAB5: VEP and IGV
Hafta 11
Systems Biology; LAB6: The Cancer Genome Atlas TCGA cbioportal.org
Hafta 12
Presentations; LAB QUIZ 2 (Labs 4-6)
Hafta 13
Presentations; MIDTERM 4-5 (in class 100 mins)
Hafta 14
Presentations

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Geçmiş GPA dağılımı 19 dönem · ort. 3.28

DönemCourse CPA
2024-2025 Spring 3.20 1 sec · 14 öğr
2023-2024 Spring 2.99 1 sec · 56 öğr
2022-2023 Spring 3.16 1 sec · 49 öğr
2021-2022 Spring 3.44 1 sec · 47 öğr
2020-2021 Spring 3.57 1 sec · 63 öğr
2019-2020 Fall 3.26 1 sec · 8 öğr
2019-2020 Spring 3.41 1 sec · 51 öğr
2018-2019 Spring 3.03 2 sec · 70 öğr
2017-2018 Spring 3.52 1 sec · 41 öğr
2016-2017 Spring 3.41 1 sec · 37 öğr

Aggregate course GPA — Bilkent STARS'tan public data. Hoca-bazlı per-section detayı için STARS evaluation report →. Öğrenci anket cevapları KVKK kapsamında defter'de tutulmaz.

⚠️ FZ engelleyen şartlar

Students are expected to know basic R and/or Python, and fundamentals of programming and statistical data analysis.

Hocalar 1 bu dönem · 4 geçmiş

Bu dönem (2025-2026 Spring) · 1 section
İlyas Chachoua
Geçmişte ders veren (4 kişi)
Özlen Konu Karakayalı, Ali Osmay Güre, Onur Emre Onat, M. Cengiz Yakıcıer